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Article

PALB2 mutations in familial breast and pancreatic cancer.

Familial cancer - 1 Jun 2011

Hofstatter Erin W, Domchek Susan M, Miron Alexander, Garber Judy, Wang Molin, Componeschi Kathryn, Boghossian Leigh, Miron Penelope L, Nathanson Katherine L, Tung Nadine

Abstract excerpt

PALB2 (Partner And Localizer of BRCA2) binds to and co-localizes with BRCA2 in DNA repair. Germline mutations in PALB2 have been identified in approximately 1-2% of familial breast cancer and 3-4% of familial pancreatic cancer cases. The goal of this study was to evaluate the prevalence of PALB2 mutations in women with breast cancer without BRCA1/2 mutations who also had a personal or family history of pancreatic...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21365267
DOI: 10.1007/s10689-011-9426-1
PMCID: PMC3836668

Genes

PALB2
BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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PALB2 mutations in familial breast and pancreatic cancer.PMID 21365267Read ↗

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Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.Semantic proximity Read ↗

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