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Article

Runs of homozygosity identify a recessive locus 12q21.31 for human adult height.

The Journal of clinical endocrinology and metabolism - 1 Aug 2010

Yang Tie-Lin, Guo Yan, Zhang Li-Shu, Tian Qing, Yan Han, Papasian Christopher J, Recker Robert R, Deng Hong-Wen

Abstract excerpt

BACKGROUND: Runs of homozygosity (ROHs) have recently been proposed to have potential recessive significance for complex traits. Human adult height is a classic complex trait with heritability estimated up to 90%, and recessive loci that contribute to adult height variation have been identified. METHODS: Using the Affymetrix 500K array set, we performed a genome-wide ROHs analysis to identify genetic loci for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20466785
DOI: 10.1210/jc.2009-1715
PMCID: PMC2913044

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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