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Article

Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction.

PloS one - 1 Jan 2013

Zhu Feng, Yan Chun-xia, Wen Yi-chong, Wang Jiayin, Bi Jinbo, Zhao Ya-ling, Wei Lai, Gao Cheng-ge, Jia Wei, Li Sheng-bin

Abstract excerpt

Dopamine D1 receptor (DRD1) modulates opioid reinforcement, reward, and opioid-induced neuroadaptation. We propose that DRD1 polymorphism affects susceptibility to opioid dependence (OD), the efficiency of transition to OD, and opioid-induced pleasure response. We analyzed potential association b...

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Identifiers

PMID: 23976958
DOI: 10.1371/journal.pone.0070805
PMCID: PMC3745389

Genes

DRD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23976958-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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