Activation of N-nitrosobis(2-oxopropyl)amine by liver and nasal mucosa tissue from intact and castrated male rats.

doi:10.1016/0304-3835(90)90008-l

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Article

Activation of N-nitrosobis(2-oxopropyl)amine by liver and nasal mucosa tissue from intact and castrated male rats.

Cancer letters - 1 Aug 1990

Lawson T A

Abstract excerpt

Methylation of liver and nasal mucosal DNA at the O6 position of guanine (O6-MeG) was measured in intact and castrated male rats after a dose of N-nitrosobis(2-oxopropyl)amine (BOP) (20 mg/kg; i.p.). There were no differences in O6-MeG persistence in liver DNA from either group. In the nasal muco...

Topics

Animals
Guanine
Liver
Male
Methylation
Methyltransferases
Mutagens
Mutation
Nasal Mucosa
Nitrosamines
O(6)-Methylguanine-DNA Methyltransferase
Orchiectomy
Rats
Rats, Inbred Strains

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