Genetics and cytogenetics of retinoblastoma.

doi:10.1016/0165-4608(92)90055-d

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Article

Genetics and cytogenetics of retinoblastoma.

Cancer genetics and cytogenetics - 1 Oct 1992

Horsthemke B

Abstract excerpt

Retinoblastoma tumor formation is initiated by loss of function of both alleles at the RB1 locus on chromosome 13. In nonhereditary retinoblastoma (60% of patients), both mutations occur during retinal development. In hereditary retinoblastoma (40% of patients), tumor formation is caused by one g...

Topics

Chromosomes, Human, Pair 13
Eye Neoplasms
Genes, Retinoblastoma
Humans
Karyotyping
Mutation
Restriction Mapping
Retinoblastoma

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