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Article

Geofold: topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability.

Proteins - 1 Mar 2012

Ramakrishnan Vibin, Srinivasan Sai Praveen, Salem Saeed M, Matthews Suzanne J, Colón Wilfredo, Zaki Mohammed, Bystroff Christopher

Abstract excerpt

Protein unfolding is modeled as an ensemble of pathways, where each step in each pathway is the addition of one topologically possible conformational degree of freedom. Starting with a known protein structure, GeoFold hierarchically partitions (cuts) the native structure into substructures using revolute joints and translations. The energy of each cut and its activation barrier are calculated using buried solvent...

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Identifiers

PMID: 22189917
DOI: 10.1002/prot.23249
PMCID: PMC3277656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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