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Article

Folding kinetics of the cooperatively folded subdomain of the IκBα ankyrin repeat domain.

Journal of molecular biology - 22 Apr 2011

DeVries Ingrid, Ferreiro Diego U, Sánchez Ignacio E, Komives Elizabeth A

Abstract excerpt

The ankyrin repeat (AR) domain of IκBα consists of a cooperative folding unit of roughly four ARs (AR1-AR4) and of two weakly folded repeats (AR5 and AR6). The kinetic folding mechanism of the cooperative subdomain, IκBα(67-206), was analyzed using rapid mixing techniques. Despite its apparent architectural simplicity, IκBα(67-206) displays complex folding kinetics, with two sequential on-pathway high-energy...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21329696
DOI: 10.1016/j.jmb.2011.02.021
PMCID: PMC3081522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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