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Article

High-Resolution Mapping of the Folding Transition State of a WW Domain.

Journal of molecular biology - 24 Apr 2016

Dave Kapil, Jäger Marcus, Nguyen Houbi, Kelly Jeffery W, Gruebele Martin

Abstract excerpt

Fast-folding WW domains are among the best-characterized systems for comparing experiments and simulations of protein folding. Recent microsecond-resolution experiments and long duration (totaling milliseconds) single-trajectory modeling have shown that even mechanistic changes in folding kinetics due to mutation can now be analyzed. Thus, a comprehensive set of experimental data would be helpful to benchmark the...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Sequence
Gene Deletion
Humans
Hydrogen Bonding
Molecular Dynamics Simulation
Molecular Sequence Data
Mutation
NIMA-Interacting Peptidylprolyl Isomerase
Peptidylprolyl Isomerase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphoproteins

Protein Folding

Protein Structure, Secondary

Protein Structure, Tertiary

Temperature

Thermodynamics

Transcription Factors

YAP-Signaling Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26880334
DOI: 10.1016/j.jmb.2016.02.008
PMCID: PMC4835268

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