Article
High-Resolution Mapping of the Folding Transition State of a WW Domain.
Journal of molecular biology - 24 Apr 2016
Dave Kapil, Jäger Marcus, Nguyen Houbi, Kelly Jeffery W, Gruebele Martin
Abstract excerpt
Fast-folding WW domains are among the best-characterized systems for comparing experiments and simulations of protein folding. Recent microsecond-resolution experiments and long duration (totaling milliseconds) single-trajectory modeling have shown that even mechanistic changes in folding kinetics due to mutation can now be analyzed. Thus, a comprehensive set of experimental data would be helpful to benchmark the...
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