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Article

Assessing the effect of loop mutations in the folding space of β2-microglobulin with molecular dynamics simulations.

International journal of molecular sciences - 22 Aug 2013

Estácio Sílvia G, Shakhnovich Eugene I, Faísca Patrícia F N

Abstract excerpt

We use molecular dynamics simulations of a full atomistic Gō model to explore the impact of selected DE-loop mutations (D59P and W60C) on the folding space of protein human β2-microglobulin (Hβ2m), the causing agent of dialysis-related amyloidosis, a conformational disorder characterized by the deposition of insoluble amyloid fibrils in the osteoarticular system. Our simulations replicate the effect of mutations...

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PMID: 23975166
DOI: 10.3390/ijms140917256
PMCID: PMC3794727

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