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Article

Calcium-Mediated Allostery of the EGF Fold.

ACS chemical biology - 15 Jun 2018

Wang Conan K, Ghani Hafiza Abdul, Bundock Anna, Weidmann Joachim, Harvey Peta J, Edwards Ingrid A, Schroeder Christina I, Swedberg Joakim E, Craik David J

Abstract excerpt

The epidermal growth factor (EGF)-like domain is one of the most abundant disulfide-containing domains in nature and is involved in many cellular processes critical to life. Although many EGF-like domains participate in calcium-dependent functions by responding to the local calcium concentration, little is known about how this responsiveness is programmed at the molecular level. Here, we reveal the structural and...

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Identifiers

PMID: 29715432
DOI: 10.1021/acschembio.8b00291

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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