Article
Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS.
PloS one - 1 Jan 2012
Diekstra Frank P, Saris Christiaan G J, van Rheenen Wouter, Franke Lude, Jansen Ritsert C, van Es Michael A, van Vught Paul W J, Blauw Hylke M, Groen Ewout J N, Horvath Steve, Estrada Karol, Rivadeneira Fernando, Hofman Albert, Uitterlinden Andre G, Robberecht Wim, Andersen Peter M, Melki Judith, Meininger Vincent, Hardiman Orla, Landers John E, Brown Robert H, Shatunov Aleksey, Shaw Christopher E, Leigh P Nigel, Al-Chalabi Ammar, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease characterized by loss of upper and lower motor neurons. ALS is considered to be a complex trait and genome-wide association studies (GWAS) have implicated a few susceptibility loci. However, many more causal loci remain to be discovered. Since it has been shown that genetic variants associated with complex traits are more likely to be...
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