Article
RPE Cells Engulf Microvesicles Secreted by Degenerating Rod Photoreceptors.
eNeuro - 1 Jan 2020
Ropelewski Philip, Imanishi Yoshikazu
Abstract excerpt
Rhodopsin is mislocalized to the inner segment plasma membrane (IS PM) in various blinding disorders including autosomal-dominant retinitis pigmentosa caused by class I rhodopsin mutations. In these disorders, rhodopsin-laden microvesicles are secreted into the extracellular milieu by afflicted photoreceptor cells. Using a Xenopus laevis model expressing class I mutant rhodopsin or Na+/K+-ATPase (NKA) fused to...
Topics
- Animals
- Mutation
- Retinal Rod Photoreceptor Cells
- Retinitis Pigmentosa
- Rhodopsin
- Xenopus laevis