Article
Rhodopsin C terminus, the site of mutations causing retinal disease, regulates trafficking by binding to ADP-ribosylation factor 4 (ARF4).
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2005
Deretic Dusanka, Williams Andrew H, Ransom Nancy, Morel Valerie, Hargrave Paul A, Arendt Anatol
Abstract excerpt
The maintenance of photoreceptor cell polarity is compromised by the rhodopsin mutations causing the human disease autosomal dominant retinitis pigmentosa. The severe form mutations occur in the C-terminal sorting signal of rhodopsin, VXPX-COOH. Here, we report that this sorting motif binds speci...
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