Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SDC1 Knockdown Suppresses Malignant Phenotypes of Breast Cancer by Modulating the MAPK Signaling Pathway.

Cancer medicine - 1 Jul 2026

Lin Weixun, Chen Xiuying, Zou Juan, Chen Yanxian, Ji Zeqi, Li Zhiyang, Xu Bo

Abstract excerpt

Breast cancer remains a leading cause of morbidity and mortality among women worldwide, necessitating in-depth research into its molecular mechanisms to improve prognosis and treatment strategies. This study investigates the expression profile and functional role of heparan sulfate proteoglycan Syndecan-1 (SDC1) in breast cancer progression, with a focus on its downstream signaling pathways. Utilizing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to MAP Kinase Signaling System

Share to Mice, Nude

Share to Neovascularization, Pathologic

Share to Syndecan-1

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 42374606
DOI: 10.1002/cam4.72016
PMCID: PMC13314544

Genes

SDC1
CCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SDC1 Knockdown Suppresses Malignant Phenotypes of Breast Cancer by Modulating the MAPK Signaling Pathway.PMID 42374606Read ↗

The Role of the Cell Surface Heparan Sulfate Proteoglycan Syndecan-3 In Breast Cancer PathophysiologySemantic proximity Read ↗

Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression.Semantic proximity Read ↗

Molecular and clinical profiles of syndecan-1 in solid and hematological cancer for prognosis and precision medicine.Semantic proximity Read ↗

Super-enhancer-hijacking RBBP7 potentiates metastasis and stemness of breast cancer via recruiting NuRD complex subunit LSD1Semantic proximity Read ↗

The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug ResistanceSemantic proximity Read ↗

Role of syndecan-4 in breast cancer pathophysiologySemantic proximity Read ↗

Syndecan-1 knockdown inhibits glioma cell proliferation and invasion by deregulating a c-src/FAK-associated signaling pathwaySemantic proximity Read ↗

The silencing of FNDC1 inhibits the tumorigenesis of breast cancer cells via modulation of the PI3K/Akt signaling pathwaySemantic proximity Read ↗

Exploring ID4 as a Driver of Aggression and a Therapeutic Target in Triple-Negative Breast CancerSemantic proximity Read ↗

HERC1 regulates breast cancer cells migration and invasionSemantic proximity Read ↗

Signaling pathway dysregulation in breast cancer.Semantic proximity Read ↗

WHSC1 promotes wnt/β-catenin signaling in a FoxM1-dependent manner facilitating proliferation, invasion and epithelial-mesenchymal transition in breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.