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Article

Designing cooperativity into the designed protein Top7.

Proteins - 1 Mar 2014

Yadahalli Shilpa, Gosavi Shachi

Abstract excerpt

The topology of the designed protein Top7 is not found in natural proteins. Top7 shows signatures of non-cooperative folding in both experimental studies and computer simulations. In particular, molecular dynamics of coarse-grained structure-based models of Top7 show a well-populated C-terminal folding-intermediate. Since most similarly sized globular proteins are cooperative folders, the non-natural topology of...

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PMID: 23966061
DOI: 10.1002/prot.24393

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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