Article
Im7 folding mechanism: misfolding on a path to the native state.
Nature structural biology - 1 Mar 2002
Capaldi Andrew P, Kleanthous Colin, Radford Sheena E
Abstract excerpt
Many proteins populate collapsed intermediate states during folding. In order to elucidate the nature and importance of these species, we have mapped the structure of the on-pathway intermediate of the four-helix protein, Im7, together with the conformational changes it undergoes as it folds to the native state. Kinetic data for 29 Im7 point mutants show that the intermediate contains three of the four helices...
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