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Article

Consequences of localized frustration for the folding mechanism of the IM7 protein.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2007

Sutto Ludovico, Lätzer Joachim, Hegler Joseph A, Ferreiro Diego U, Wolynes Peter G

Abstract excerpt

In the laboratory, IM7 has been found to have an unusual folding mechanism in which an "on-pathway" intermediate with nonnative interactions is formed. We show that this intermediate is a consequence of an unusual cluster of highly frustrated interactions in the native structure. This cluster is involved in the binding of IM7 to its target, Colicin E7. Redesign of residues in this cluster to eliminate frustration...

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Identifiers

PMID: 18077415
DOI: 10.1073/pnas.0709922104
PMCID: PMC2148258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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