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Article

An RBPMS-driven splicing regulatory axis including MBNL1, RBFOX2, and QK promotes smooth muscle cell contractile identity.

Nucleic acids research - 26 Nov 2025

Huang Yuling, Kollyfas Rafael, Partridge Ruth, Gooding Clare, Sinha Sanjay, Mohorianu Irina, Jacob Aishwarya, Smith Christopher W J

Abstract excerpt

Phenotype switching of vascular smooth muscle cells (SMCs) between contractile and more proliferative and motile states is associated with cardiovascular disease and is underpinned by transcriptional and alternative splicing (AS) programs. We previously showed the RNA-binding protein (RBP) RNA Binding Protein with Multiple Splicing (RBPMS) to be a master regulator of AS in differentiated SMCs. Although changes in...

Read the complete abstract on PubMed

Topics

RNA-Binding Proteins
RNA Splicing Factors
Myocytes, Smooth Muscle
Humans
Alternative Splicing
Cell Movement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Muscle Contraction

Cell Proliferation

Animals

Repressor Proteins

Cells, Cultured

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 41428739
DOI: 10.1093/nar/gkaf1386
PMCID: PMC12721327

Genes

RBPMS
MBNL1
RBFOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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