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Article

Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1990

Carroll M C, Fathallah D M, Bergamaschini L, Alicot E M, Isenman D E

Abstract excerpt

The C4B isotype of the fourth component of human complement (C4) displays 3- to 4-fold greater hemolytic activity than does its other isotype C4A. This correlates with differences in their covalent binding efficiencies to erythrocytes coated with antibody and complement C1. C4A binds to a greater extent when C1 is on IgG immune aggregates. The differences in covalent binding properties correlate only with amino...

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Identifiers

PMID: 2395880
DOI: 10.1073/pnas.87.17.6868
PMCID: PMC54639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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