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Article

Structure-based mapping of DAF active site residues that accelerate the decay of C3 convertases.

The Journal of biological chemistry - 22 Jun 2007

Kuttner-Kondo Lisa, Hourcade Dennis E, Anderson Vernon E, Muqim Nasima, Mitchell Lynne, Soares Dinesh C, Barlow Paul N, Medof M Edward

Abstract excerpt

Focused complement activation on foreign targets depends on regulatory proteins that decay the bimolecular C3 convertases. Although this process is central to complement control, how the convertases engage and disassemble is not established. The second and third complement control protein (CCP) modules of the cell surface regulator, decay-accelerating factor (DAF, CD55), comprise the simplest structure mediating...

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PMID: 17395591
DOI: 10.1074/jbc.M611650200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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