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Article

Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52

1 Apr 1998

Abstract excerpt

Activation of the complement cascade by immunoglobulin G (IgG) plays a major role in the host defense against pathogens. Using recombinant human antibodies specific for the leucocyte antigen CD52, different allotypes of human IgG1 subclass were compared for their ability to activate human complement. In addition the roles of the different length hinge regions of IgG1 and IgG3 were investigated. It was found that...

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Identifiers

PMID: 9659234
DOI: 10.1046/j.1365-2567.1998.00472.x

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