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Article

Structural difference in the complement activation site of human IgG1 and IgG3.

Scandinavian journal of immunology - 1 Dec 2009

Michaelsen T E, Sandlie I, Bratlie D B, Sandin R H, Ihle O

Abstract excerpt

The C1q binding epicentre on IgG molecules involves residues Asp(270), Lys(322), Pro(329) and Pro(331) in the C(H)2 domain. IgG1 and IgG3 are usually the most efficient of the four human IgG subclasses in activating complement and they both share all these residues. To reveal possible differences...

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Identifiers

PMID: 19906198
DOI: 10.1111/j.1365-3083.2009.02338.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19906198-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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