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Article

Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation.

1 Aug 1993

Abstract excerpt

Although very similar in sequence, the four subclasses of human immunoglobulin G (IgG) differ markedly in their ability to activate complement. Glu318-Lys320-Lys322 has been identified as a key binding motif for the first component of complement, C1q, and is present in all isotypes of Ig capable of activating complement. This motif, however, is present in all subclasses of human IgG, including those that show...

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PMID: 8340761
DOI: 10.1084/jem.178.2.661

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Structural features of human immunoglobulin G that determine isotype-specific differences in complement activation.PMID 8340761Read ↗

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