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Article

Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency

14 Jan 2009

Abstract excerpt

Recent research has emphasized the notion that human immunodeficiency virus type 1 (HIV-1) latency is controlled by a restrictive histone code at, or DNA methylation of, the integrated viral promoter (long terminal repeat [LTR]). The present concept of HIV-1 latency has essentially been patterned from the principles of cellular gene regulation. Here we introduce an experimental system that allows for the...

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PMID: 19144703
DOI: 10.1128/jvi.02058-08

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