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Article

GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm.

PLoS genetics - 1 Jan 2013

Bottolo Leonardo, Chadeau-Hyam Marc, Hastie David I, Zeller Tanja, Liquet Benoit, Newcombe Paul, Yengo Loic, Wild Philipp S, Schillert Arne, Ziegler Andreas, Nielsen Sune F, Butterworth Adam S, Ho Weang Kee, Castagné Raphaële, Munzel Thomas, Tregouet David, Falchi Mario, Cambien François, Nordestgaard Børge G, Fumeron Fredéric, Tybjærg-Hansen Anne, Froguel Philippe, Danesh John, Petretto Enrico, Blankenberg Stefan, Tiret Laurence, Richardson Sylvia

Abstract excerpt

Genome-wide association studies (GWAS) yielded significant advances in defining the genetic architecture of complex traits and disease. Still, a major hurdle of GWAS is narrowing down multiple genetic associations to a few causal variants for functional studies. This becomes critical in multi-phe...

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PMID: 23950726
DOI: 10.1371/journal.pgen.1003657
PMCID: PMC3738451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23950726-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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