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Article

Development of GMDR-GPU for gene-gene interaction analysis and its application to WTCCC GWAS data for type 2 diabetes.

PloS one - 1 Jan 2013

Zhu Zhixiang, Tong Xiaoran, Zhu Zhihong, Liang Meimei, Cui Wenyan, Su Kunkai, Li Ming D, Zhu Jun

Abstract excerpt

Although genome-wide association studies (GWAS) have identified a significant number of single-nucleotide polymorphisms (SNPs) associated with many complex human traits, the susceptibility loci identified so far can explain only a small fraction of the genetic risk. Among other possible explanations, the lack of a comprehensive examination of gene-gene interaction (G×G) is often considered a source of the missing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23626757
DOI: 10.1371/journal.pone.0061943
PMCID: PMC3633958

Genes

CELF4
FTO
RUNX1
TSPAN8

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