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Article

GPA-Tree: statistical approach for functional-annotation-tree-guided prioritization of GWAS results.

Bioinformatics (Oxford, England) - 27 Jan 2022

Khatiwada Aastha, Wolf Bethany J, Yilmaz Ayse Selen, Ramos Paula S, Pietrzak Maciej, Lawson Andrew, Hunt Kelly J, Kim Hang J, Chung Dongjun

Abstract excerpt

MOTIVATION: In spite of great success of genome-wide association studies (GWAS), multiple challenges still remain. First, complex traits are often associated with many single nucleotide polymorphisms (SNPs), each with small or moderate effect sizes. Second, our understanding of the functional mechanisms through which genetic variants are associated with complex traits is still limited. To address these...

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PMID: 34849578
DOI: 10.1093/bioinformatics/btab802
PMCID: PMC10060690

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