Article
MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET.
Neurology - 28 Dec 2004
Mosconi L, Perani D, Sorbi S, Herholz K, Nacmias B, Holthoff V, Salmon E, Baron J-C, De Cristofaro M T R, Padovani A, Borroni B, Franceschi M, Bracco L, Pupi A
Abstract excerpt
OBJECTIVES: To investigate whether the combination of fluoro-2-deoxy-d-glucose (FDG) PET measures with the APOE genotype would improve prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHOD: After 1 year, 8 of 37 patients with MCI converted to AD (22%). Differences in baseline regional glucose metabolic rate (rCMRglc) across groups were assessed on a voxel-based basis...
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