Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.

Human molecular genetics - 15 Jun 2015

Malik Manasi, Chiles Joe, Xi Hualin S, Medway Christopher, Simpson James, Potluri Shobha, Howard Dianna, Liang Ying, Paumi Christian M, Mukherjee Shubhabrata, Crane Paul, Younkin Steven, Fardo David W, Estus Steven

Abstract excerpt

The CD33 single-nucleotide polymorphism (SNP) rs3865444 has been associated with the risk of Alzheimer's disease (AD). Rs3865444 is in linkage disequilibrium with rs12459419 which has been associated with efficacy of an acute myeloid leukemia (AML) chemotherapeutic agent based on a CD33 antibody. We seek to evaluate the extent to which CD33 genetics in AD and AML can inform one another and advance human disease...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Alzheimer Disease
Share to Antibodies, Monoclonal, Humanized
Share to Gene Expression
Share to Introns
Share to Leukemia, Myeloid, Acute
Share to RNA Stability
Share to Sialic Acid Binding Ig-like Lectin 3

Source

Open in PubMed Open full text

Identifiers

PMID: 25762156
DOI: 10.1093/hmg/ddv092
PMCID: PMC4498153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia.PMID 25762156Read ↗

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.Semantic proximity Read ↗

CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility.Semantic proximity Read ↗

CD33 mRNA Has Elevated Expression Levels in the Leukocytes of Peripheral Blood in Patients with Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex.Semantic proximity Read ↗

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer riskSemantic proximity Read ↗

Functional Effects of CD33 SNP rs12459419 on Microglial Gene Regulation and Alzheimer’s Disease RiskSemantic proximity Read ↗

CD33 and SHP-1/PTPN6 Interaction in Alzheimer's Disease.Semantic proximity Read ↗

CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s DiseaseSemantic proximity Read ↗

Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study.Semantic proximity Read ↗

CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer’s Disease SusceptibilitySemantic proximity Read ↗

The CD33 short isoform is a gain-of-function variant that enhances Aβ1-42 phagocytosis in microglia.Semantic proximity Read ↗

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.