Factors influencing ascertainment bias of microsatellite allele sizes: impact on estimates of mutation rates.

Abstract excerpt

Microsatellite loci play an important role as markers for identification, disease gene mapping, and evolutionary studies. Mutation rate, which is of fundamental importance, can be obtained from interspecies comparisons, which, however, are subject to ascertainment bias. This bias arises, for example, when a locus is selected on the basis of its large allele size in one species (cognate species 1), in which it is...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pan troglodytes
• Share to Evolution, Molecular
• Share to Genetic Drift