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Article

Heterogeneity of microsatellite mutations within and between loci, and implications for human demographic histories.

Genetics - 1 Mar 1998

Di Rienzo A, Donnelly P, Toomajian C, Sisk B, Hill A, Petzl-Erler M L, Haines G K, Barch D H

Abstract excerpt

Microsatellites have been widely used to reconstruct human evolution. However, the efficient use of these markers relies on information regarding the process producing the observed variation. Here, we present a novel approach to the locus-by-locus characterization of this process. By analyzing somatic mutations in cancer patients, we estimated the distributions of mutation size for each of 20 loci. The same loci...

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Identifiers

PMID: 9539441
DOI: 10.1093/genetics/148.3.1269
PMCID: PMC1460025

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