Article
Microsatellites are molecular clocks that support accurate inferences about history.
Molecular biology and evolution - 1 May 2009
Sun James X, Mullikin James C, Patterson Nick, Reich David E
Abstract excerpt
Microsatellite length mutations are often modeled using the generalized stepwise mutation process, which is a type of random walk. If this model is sufficiently accurate, one can estimate the coalescence time between alleles of a locus after a mathematical transformation of the allele lengths. When large-scale microsatellite genotyping first became possible, there was substantial interest in using this approach...
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