Heterozygosity increases microsatellite mutation rate, linking it to demographic history.

Abstract excerpt

BACKGROUND: Biochemical experiments in yeast suggest a possible mechanism that would cause heterozygous sites to mutate faster than equivalent homozygous sites. If such a process operates, it could undermine a key assumption at the core of population genetic theory, namely that mutation rate and population size are indpendent, because population expansion would increase heterozygosity that in turn would increase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Demography
• Share to Genetics, Population
• Share to Genotype