Article
Association between genetic polymorphisms in Ca(v)2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery.
PloS one - 1 Jan 2013
Ide Soichiro, Nishizawa Daisuke, Fukuda Ken-ichi, Kasai Shinya, Hasegawa Junko, Hayashida Masakazu, Minami Masabumi, Ikeda Kazutaka
Abstract excerpt
Individual differences in the sensitivity to fentanyl, a widely used opioid analgesic, lead to different proper doses of fentanyl, which can hamper effective pain treatment. Voltage-activated Ca(2+) channels (VACCs) play a crucial role in the nervous system by controlling membrane excitability and calcium signaling. Ca(v)2.3 (R-type) VACCs have been especially thought to play critical roles in pain pathways and...
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