Article
Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery.
Pain - 15 Dec 2009
Fukuda Kenichi, Hayashida Masakazu, Ide Soichiro, Saita Naoko, Kokita Yoshihiko, Kasai Shinya, Nishizawa Daisuke, Ogai Yasukazu, Hasegawa Junko, Nagashima Makoto, Tagami Megumi, Komatsu Hiroshi, Sora Ichiro, Koga Hisashi, Kaneko Yuzuru, Ikeda Kazutaka
Abstract excerpt
Individual differences in sensitivity to fentanyl, a widely used opioid analgesic, can hamper effective pain treatment. Still controversial is whether the single nucleotide polymorphisms (SNPs) of the human OPRM1 gene encoding the mu-opioid receptor influence the analgesic effects of opioids. We...
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