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Article

Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.

Molecular pain - 3 Dec 2014

Ide Soichiro, Nishizawa Daisuke, Fukuda Ken-ichi, Kasai Shinya, Hasegawa Junko, Hayashida Masakazu, Minami Masabumi, Ikeda Kazutaka

Abstract excerpt

BACKGROUND: The P2X7 receptor is a member of the P2X family of adenosine 5'-triphosphate-gated cation channels. Several recent studies have demonstrated that this receptor is involved in mechanisms related to pain and inflammation. However, unknown is whether polymorphisms of the P2RX7 gene that encodes the human P2X7 receptor influence pain sensitivity and analgesic effects of opioids. The P2RX7 gene is known to...

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Identifiers

PMID: 25472448
DOI: 10.1186/1744-8069-10-75
PMCID: PMC4265416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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