Opposite Associations Between the rs3845446 Single-Nucleotide Polymorphism of the CACNA1E Gene and Postoperative Pain-Related Phenotypes in Gastrointestinal Surgery Versus Previously Reported Orthognathic Surgery.

doi:10.1016/j.jpain.2016.07.001

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Article

Opposite Associations Between the rs3845446 Single-Nucleotide Polymorphism of the CACNA1E Gene and Postoperative Pain-Related Phenotypes in Gastrointestinal Surgery Versus Previously Reported Orthognathic Surgery.

The journal of pain - 1 Oct 2016

Amano Kojiro, Nishizawa Daisuke, Mieda Tsutomu, Tsujita Miki, Kitamura Akira, Hasegawa Junko, Inada Eiichi, Hayashida Masakazu, Ikeda Kazutaka

Abstract excerpt

UNLABELLED: Cav2.3 (R-type) voltage-activated Ca(2+) channels (VACCs), encoded by the calcium channel, voltage-dependent, R-type, α1E subunit (CACNA1E) gene, are responsible for transmission of somatic inflammatory pain, and activation of antinociception elicited by visceral inflammatory pain stimuli. Carriers of the minor G allele of the rs3845446 single-nucleotide polymorphism (SNP) of the CACNA1E gene...

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PMID: 27480382
DOI: 10.1016/j.jpain.2016.07.001

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