Article
Global shapes of F-actin depolymerization-competent minimal gelsolins: insight into the role of g2-g3 linker in pH/Ca2+ insensitivity of the first half.
The Journal of biological chemistry - 27 Sept 2013
Peddada Nagesh, Sagar Amin, Rathore Yogendra S, Choudhary Vikas, Pattnaik U Bharat K, Khatri Neeraj, Garg Renu, Ashish
Abstract excerpt
Because of its ability to rapidly depolymerize F-actin, plasma gelsolin has emerged as a therapeutic molecule in different disease conditions. High amounts of exogenous gelsolin are, however, required to treat animal models of different diseases. Knowing that the F-actin depolymerizing property of gelsolin resides in its N terminus, we made several truncated versions of plasma gelsolin. The smaller versions,...
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