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Article

IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.

PloS one - 1 Jan 2014

Real Luis M, Neukam Karin, Herrero Rocío, Guardiola Josep M, Reiberger Thomas, Rivero-Juarez Antonio, Salazar Juliana, Mandorfer Mattias, Merino Dolores, Soriano Vicente, Rivero Antonio, Macías Juan, Pineda Juan A, Caruz Antonio

Abstract excerpt

OBJECTIVES: The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV...

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PMID: 24748394
DOI: 10.1371/journal.pone.0095515
PMCID: PMC3991683

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