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Article

Predictive value of interferon-lambda gene polymorphisms for treatment response in chronic hepatitis C.

PloS one - 1 Jan 2014

Susser Simone, Herrmann Eva, Lange Christian, Hamdi Nabila, Müller Tobias, Berg Thomas, Perner Dany, Zeuzem Stefan, Sarrazin Christoph

Abstract excerpt

BACKGROUND: IL28B gene polymorphism is the best baseline predictor of response to interferon alfa-based antiviral therapies in chronic hepatitis C. Recently, a new IFN-L4 polymorphism was identified as first potential functional variant for induction of IL28B expression. Individualization of interferon alfa-based therapies based on a combination of IL28B/IFN-L4 polymorphisms may help to optimize virologic outcome...

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Identifiers

PMID: 25393304
DOI: 10.1371/journal.pone.0112592
PMCID: PMC4231027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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