Article
IFNL4-ΔG genotype is associated with slower viral clearance in hepatitis C, genotype-1 patients treated with sofosbuvir and ribavirin.
The Journal of infectious diseases - 1 Jun 2014
Meissner Eric G, Bon Dimitra, Prokunina-Olsson Ludmila, Tang Wei, Masur Henry, O'Brien Thomas R, Herrmann Eva, Kottilil Shyamasundaran, Osinusi Anuoluwapo
Abstract excerpt
Response to pegylated interferon-alpha and ribavirin (IFN-α/RBV) treatment for chronic hepatitis C virus (HCV) infection is influenced by host genetic factors, but their role for IFN-α-free, direct-acting antiviral (DAA) regimens is unclear. An exonic deletion allele (IFNL4-ΔG) bolsters the established association with IFN-α/RBV therapy treatment outcome of another IFNL4 variant, rs12979860, which is located...
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