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IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients.

AIDS (London, England) - 2 Jan 2014

Franco Sandra, Aparicio Ester, Parera Mariona, Clotet Bonaventura, Tural Cristina, Martinez Miguel Angel

Abstract excerpt

A new transiently induced region (interferon-λ 4 protein; IFNL4) harbouring a dinucleotide variant ss469415590 (TT or ΔG), upstream of IFNL3 (IL28B), was recently found to be associated with hepatitis C virus (HCV) clearance. To determine the effect of IFLN4 ss469415590 variation on the HCV response to IFN-based therapy in HCV/HIV-1 coinfected patients, ss469415590 was genotyped in a cohort of 207 patients from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24072198
DOI: 10.1097/QAD.0000000000000052

Genes

IFNL3

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IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients.PMID 24072198Read ↗

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IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against Hepatitis C Virus genotype 1 or 4 in Caucasians.Semantic proximity Read ↗

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The novel ss469415590 variant predicts virological response to therapy in patients with chronic hepatitis C virus type 1 infection.Semantic proximity Read ↗

IFNL4 ss469415590 polymorphism contributes to treatment decisions in patients with chronic hepatitis C virus genotype 1b, but not 2a, infection.Semantic proximity Read ↗

Correlation of interferon-lambda 4 ss469415590 with the hepatitis C virus treatment response and its comparison with interleukin 28b polymorphisms in predicting a sustained virological response: a meta-analysis.Semantic proximity Read ↗

Genetic variants in interferon-λ 4 influences HCV clearance in Chinese Han population.Semantic proximity Read ↗

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