Article
A short acidic motif in ARF guards against mitochondrial dysfunction and melanoma susceptibility.
Nature communications - 5 Nov 2014
Christensen Claus, Bartkova Jirina, Mistrík Martin, Hall Arnaldur, Lange Marina Krarup, Ralfkiær Ulrik, Bartek Jiri, Guldberg Per
Abstract excerpt
ARF is a small, highly basic protein that can be induced by oncogenic stimuli and exerts growth-inhibitory and tumour-suppressive activities through the activation of p53. Here we show that, in human melanocytes, ARF is cytoplasmic, constitutively expressed, and required for maintaining low steady-state levels of superoxide under conditions of mitochondrial dysfunction. This mitochondrial activity of ARF is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.