Article
Oncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.
PloS one - 1 Jan 2013
Buchanan Christina M, Dickson James M J, Lee Woo-Jeong, Guthridge Mark A, Kendall Jackie D, Shepherd Peter R
Abstract excerpt
In addition to lipid kinase activity, the class-I PI 3-kinases also function as protein kinases targeting regulatory autophosphorylation sites and exogenous substrates. The latter include a recently identified regulatory phosphorylation of the GM-CSF/IL-3 βc receptor contributing to survival of acute myeloid leukaemia cells. Previous studies suggested differences in the protein kinase activity of the 4 isoforms...
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