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Article

Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.

Biochemical Society transactions - 1 Feb 2014

Flanagan Jack U, Shepherd Peter R

Abstract excerpt

The PI3K (phosphoinositide 3-kinase) p110α isoform is activated by oncogenic mutations in many cancers. This has stimulated intense interest in identifying inhibitors of the PI3K pathway as well as p110α-selective inhibitors, and understanding the mechanisms underlying activation by the oncogenic mutations. In the present article, we review recent progress in the structure and function of the p110α enzyme and two...

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Identifiers

PMID: 24450638
DOI: 10.1042/BST20130255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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