Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Abstract excerpt

The PI3-kinase pathway is commonly activated in tumors, most often by loss of PTEN lipid phosphatase activity or the amplification or mutation of p110α. Oncogenic mutants have commonly been found in p110α, but rarely in any of the other catalytic subunits of class I PI3-kinases. We here characterize a p110β helical domain mutation, E633K, first identified in a Her2-positive breast cancer. The mutation increases...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Class Ia Phosphatidylinositol 3-Kinase
• Share to Enzyme Activation