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Article

The regulation of class IA PI 3-kinases by inter-subunit interactions.

Current topics in microbiology and immunology - 1 Jan 2010

Backer Jonathan M

Abstract excerpt

Phosphoinositide 3-kinases (PI 3-kinases) are activated by growth factor and hormone receptors, and regulate cell growth, survival, motility, and responses to changes in nutritional conditions (Engelman et al. 2006). PI 3-kinases have been classified according to their subunit composition and their substrate specificity for phosphoinositides (Vanhaesebroeck et al. 2001). The class IA PI 3-kinase is a heterodimer...

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Identifiers

PMID: 20544340
DOI: 10.1007/82_2010_52
PMCID: PMC3234103

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Source receipt: pubmed, retrieved 7 Sept 2026.

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