Article
Fc gamma receptor 3B (FCGR3B-c.233C>A-rs5030738) polymorphism modifies the protective effect of malaria specific antibodies in Ghanaian children.
The Journal of infectious diseases - 15 Jan 2014
Adu Bright, Jepsen Micha Phill Grønholm, Gerds Thomas A, Kyei-Baafour Eric, Christiansen Michael, Dodoo Daniel, Theisen Michael
Abstract excerpt
Immunoglobulin G (IgG) cross-linking with Fc gamma receptor IIIB (FcγRIIIB) triggers neutrophil degranulation, releasing reactive oxygen species with high levels associated with protection against malaria. The FCGR3B-c.233C>A polymorphism thought to influence the interaction between IgG and FcγRIIIB was recently associated with malaria. We studied the statistical interaction between glutamate rich protein...
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