Article
Susceptibility to Plasmodium falciparum Malaria: Influence of Combined Polymorphisms of IgG3 Gm Allotypes and Fc Gamma Receptors IIA, IIIA, and IIIB.
Frontiers in immunology - 1 Jan 2020
Fall Abdou Khadre Dit Jadir, Dechavanne Celia, Sabbagh Audrey, Guitard Evelyne, Milet Jacqueline, Garcia André, Dugoujon Jean-Michel, Courtin David, Migot-Nabias Florence
Abstract excerpt
The binding of immunoglobulin (Ig) to Fc gamma receptors (FcgR) at the immune cell surface is an important step to initiate immunological defense against malaria. However, polymorphisms in receptors and/or constant regions of the IgG heavy chains may modulate this binding. Here, we investigated whether polymorphisms located in FcgR and constant regions of the heavy chain of IgG are associated with susceptibility...
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