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Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex.

Nucleic acids research - 1 Nov 2013

Lukaszewicz Agnieszka, Howard-Till Rachel A, Loidl Josef

Abstract excerpt

Mus81 resolvase and Sgs1 helicase have well-established roles in mitotic DNA repair. Moreover, Mus81 is part of a minor crossover (CO) pathway in the meiosis of budding yeast, plants and vertebrates. The major pathway depends on meiosis-specific synaptonemal complex (SC) formation, ZMM proteins and the MutLγ complex for CO-directed resolution of joint molecule (JM)-recombination intermediates. Sgs1 has also been...

Topics

Cell Nucleus
Chromatids
Chromosome Segregation
DNA
DNA Breaks, Double-Stranded
Endodeoxyribonucleases
Escherichia coli Proteins
Meiosis
Mutation
RNA Interference
RecQ Helicases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinases

Recombination, Genetic

Synaptonemal Complex

Tetrahymena thermophila

Source

Open in PubMed Open full text

Identifiers

PMID: 23935123
DOI: 10.1093/nar/gkt703
PMCID: PMC3814389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex.PMID 23935123Read ↗

Msh4 and Msh5 function in SC-independent chiasma formation during the streamlined meiosis of Tetrahymena.Semantic proximity Read ↗

Controlling meiotic recombinational repair - specifying the roles of ZMMs, Sgs1 and Mus81/Mms4 in crossover formation.Semantic proximity Read ↗

Single Holliday junctions are intermediates of meiotic recombination.Semantic proximity Read ↗

Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis.Semantic proximity Read ↗

Delineation of joint molecule resolution pathways in meiosis identifies a crossover-specific resolvase.Semantic proximity Read ↗

BLM helicase ortholog Sgs1 is a central regulator of meiotic recombination intermediate metabolism.Semantic proximity Read ↗

RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination.Semantic proximity Read ↗

The human Holliday junction resolvase GEN1 rescues the meiotic phenotype of a Schizosaccharomyces pombe mus81 mutant.Semantic proximity Read ↗

MUS81 generates a subset of MLH1-MLH3-independent crossovers in mammalian meiosis.Semantic proximity Read ↗

The RecQ helicase AtRECQ4A is required to remove inter-chromosomal telomeric connections that arise during meiotic recombination in Arabidopsis.Semantic proximity Read ↗

Synaptonemal complex formation and meiotic checkpoint signaling are linked to the lateral element protein Red1.Semantic proximity Read ↗

Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis.Semantic proximity Read ↗

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